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Varshney A, Jia Z, Howe MD, Keiler KC*, Baughn AD*. A trans-Translation Inhibitor is Potentiated by Zinc and Kills Mycobacterium tuberculosis and Nontuberculous Mycobacteria. ACS Infectious Diseases. 2025 Apr 9. doi: https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00963 (*co-corresponding authors)
Brody SI, Buonomo JA, Orimoloye MO, Jia Z, Sharma S, Brown CD, Baughn AD, Aldrich CC. A Nucleophilic Activity-Based Probe Enables Profiling of PLP-Dependent Enzymes. Chembiochem. 2023 Jan 18. doi: 10.1002/cbic.202200669. PMID: 36652345
Cole MS, Howe MD, Buonomo JA, Sharma S, Lamont EA, Brody SI, Mishra NK, Minato Y, Thiede JM, Baughn AD, Aldrich CC. Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis. Chemistry. 2022 Jun 13:e202200995. doi: 10.1002/chem.202200995. Online ahead of print. PMID: 35697660
Green KD, Pang AH, Thamban Chandrika N, Garzan A, Baughn AD, Tsodikov OV, Garneau-Tsodikova S. Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents. ACS Infect Dis. 2022 Apr 8;8(4):757-767. doi: 10.1021/acsinfecdis.1c00450. Epub 2022 Mar 3. PMID: 35239306
Hegde PV, Howe MD, Zimmerman MD, Boshoff HIM, Sharma S, Remache B, Jia Z, Pan Y, Baughn AD, Dartois V, Aldrich CC. Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). Eur J Med Chem. 2022 Feb 19;232:114201. doi: 10.1016/j.ejmech.2022.114201. Epub ahead of print. PMID: 35219151.
Thiede JM, Dillon NA, Howe MD, Aflakpui R, Modlin SJ, Hoffner SE, Valafar F, Minato Y, Baughn AD. Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis. mBio. 2022 Feb 1;13(1):e0043921. doi: 10.1128/mbio.00439-21. Epub ahead of print. PMID: 35100871; PMCID: PMC8805019.
Modlin SJ, Elghraoui A, Gunasekaran D, Zlotnicki AM, Dillon NA, Dhillon N, Kuo N, Robinhold C, Chan CK, Baughn AD, Valafar F. Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes. mSystems. 2021 Nov-Dec; 6(6): e00673-21. Published online 2021 Nov 2. doi: 10.1128/mSystems.00673-21 PMCID: PMC8562490.
Simonson AW, Mongia AS, Aronson MR, Alumasa JN, Chan DC, Lawanprasert A, Howe MD, Bolotsky A, Mal TK, George C, Ebrahimi A, Baughn AD, Proctor EA, Keiler KC, Medina SH. Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry. Nat Biomed Eng. 2021 May;5(5):467-480. doi: 10.1038/s41551-020-00665-x. Epub 2021 Jan 4. PMID: 33390588; PMCID: PMC8131206.
Tateishi Y, Minato Y, Baughn AD, Ohnishi H, Nishiyama A, Ozeki Y, Matsumoto S. Genome-wide identification of essential genes in Mycobacterium intracellulare by transposon sequencing - Implication for metabolic remodeling. Sci Rep. 2020 Mar 25;10(1):5449. doi: 10.1038/s41598-020-62287-2. PMID: 32214196; PMCID: PMC7096427.
Lamont EA, Dillon NA, Baughn AD. The Bewildering Antitubercular Action of Pyrazinamide. Microbiol Mol Biol Rev. 2020 Mar 4;84(2):e00070-19. doi: 10.1128/MMBR.00070-19. PMID: 32132245; PMCID: PMC7062198.
Lamont EA, Baughn AD. Impact of the host environment on the antitubercular action of pyrazinamide. EBioMedicine. 2019 Nov;49:374-380. doi: 10.1016/j.ebiom.2019.10.014. Epub 2019 Oct 25. PMID: 31669220; PMCID: PMC6945238.
Kordus SL, Baughn AD. Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance. Medchemcomm. 2019 May 8;10(6):880-895. doi: 10.1039/c9md00078j. PMID: 31303985; PMCID: PMC6595967.
Minato Y, Gohl DM, Thiede JM, Chacón JM, Harcombe WR, Maruyama F, Baughn AD. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. mSystems. 2019 Jun 25;4(4):e00070-19. doi: 10.1128/mSystems.00070-19. PMID: 31239393; PMCID: PMC6593218.
Howe MD, Kordus SL, Cole MS, Bauman AA, Aldrich CC, Baughn AD, Minato Y. Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2018 Nov 12;8:399. doi: 10.3389/fcimb.2018.00399. PMID: 30483484; PMCID: PMC6240602.
Minato Y, Dawadi S, Kordus SL, Sivanandam A, Aldrich CC, Baughn AD. Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole. Nat Commun. 2018 Mar 8;9(1):1003. doi: 10.1038/s41467-018-03447-x. PMID: 29520101; PMCID: PMC5843663.
Minato Y, Baughn AD. Subversion of Metabolic Wasting as the Mechanism for folM-Linked Sulfamethoxazole Resistance. mBio. 2017 Nov 28;8(6):e01769-17. doi: 10.1128/mBio.01769-17. PMID: 29184016; PMCID: PMC5705918.
Dawadi S, Kordus SL, Baughn AD, Aldrich CC. Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates. Org Lett. 2017 Oct 6;19(19):5220-5223. doi: 10.1021/acs.orglett.7b02487. Epub 2017 Sep 19. PMID: 28926267.
Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler KC. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells. ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi: 10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7. PMID: 28762275; PMCID: PMC5594445.
Dillon NA, Peterson ND, Feaga HA, Keiler KC, Baughn AD. Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA. Sci Rep. 2017 Jul 21;7(1):6135. doi: 10.1038/s41598-017-06415-5. PMID: 28733601; PMCID: PMC5522395.
Thiede JM, Kordus SL, Turman BJ, Buonomo JA, Aldrich CC, Minato Y, Baughn AD. Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates. Sci Rep. 2016 Dec 1;6:38083. doi: 10.1038/srep38083. PMID: 27905500; PMCID: PMC5131483.
Rosen BC, Dillon NA, Peterson ND, Minato Y, Baughn AD. Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02130-16. doi: 10.1128/AAC.02130-16. PMID: 27855077; PMCID: PMC5278697.
Peterson ND, Rosen BC, Dillon NA, Baughn AD. Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015 Dec;59(12):7320-6. doi: 10.1128/AAC.00967-15. Epub 2015 Sep 14. PMID: 26369957; PMCID: PMC4649215.
Baughn AD, Rhee KY. Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosis. Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0026-2013. PMID: 26103978
Minato Y, Thiede JM, Kordus SL, McKlveen EJ, Turman BJ, Baughn AD. Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance. Antimicrob Agents Chemother. 2015 Sep;59(9):5097-106. doi: 10.1128/AAC.00647-15. Epub 2015 Jun 1. PMID: 26033719; PMCID: PMC4538520.
Dillon NA, Peterson ND, Rosen BC, Baughn AD. Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide. Antimicrob Agents Chemother. 2014 Dec;58(12):7258-63. doi: 10.1128/AAC.04028-14. Epub 2014 Sep 22. PMID: 25246400; PMCID: PMC4249577.
Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI. Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence. mBio. 2014 Jun 3;5(3):e01106-14. doi: 10.1128/mBio.01106-14. PMID: 24895305
Zhao F, Wang XD, Erber LN, Luo M, Guo AZ, Yang SS, Gu J, Turman BJ, Gao YR, Li DF, Cui ZQ, Zhang ZP, Bi LJ, Baughn AD, Zhang XE, Deng JY. Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014;58(3):1479-87. doi: 10.1128/AAC.01775-13. Epub 2013 Dec 23. PMID: 24366731
Ahmad Z, Tyagi S, Minkowsk A, Almeida D, Nuermberger EL, Peck KM, Welch JT, Baughn AD, Jacobs WR Jr, Grosset JH. Activity of 5-chloro-pyrazinamide in mice infected with Mycobacterium tuberculosis or Mycobacterium bovis. Indian J Med Res. 2012 Nov;136(5):808-14. PMID: 23287128
Meehan BM, Baughn AD, Gallegos R, Malamy MH. Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12153-8. doi: 10.1073/pnas.1203796109. Epub 2012 Jul 9. PMID: 22778399
Besanceney-Webler C, Jiang H, Wang W, Baughn AD, Wu P. Metabolic labeling of fucosylated glycoproteins in Bacteroidales species. Bioorg Med Chem Lett. 2011 Sep 1;21(17):4989-92. doi: 10.1016/j.bmcl.2011.05.038. Epub 2011 May 24. PMID: 21676614
Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR Jr. Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions. Antimicrob Agents Chemother. 2011 Aug;55(8):3889-98. doi: 10.1128/AAC.00266-11. Epub 2011 May 31. PMID: 21628538
Baughn AD, Deng J, Vilchèze C, Riestra A, Welch JT, Jacobs WR Jr, Zimhony O. Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy. Antimicrob Agents Chemother. 2010 Dec;54(12):5323-8. doi: 10.1128/AAC.00529-10. Epub 2010 Sep 27. PMID: 20876380
Pruksakorn P, Arai M, Kotoku N, Vilchèze C, Baughn AD, Moodley P, Jacobs WR Jr, Kobayashi M. Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3658-63. doi: 10.1016/j.bmcl.2010.04.100. Epub 2010 Apr 26. PMID: 20483615
Baughn AD, Garforth SJ, Vilchèze C, Jacobs WR Jr. An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. PLoS Pathog. 2009 Nov;5(11):e1000662. doi: 10.1371/journal.ppat.1000662. Epub 2009 Nov 20. PMID: 19936047
Arai M, Sobou M, Vilchéze C, Baughn A, Hashizume H, Pruksakorn P, Ishida S, Matsumoto M, Jacobs WR Jr, Kobayashi M. Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent. Bioorg Med Chem. 2008 Jul 15;16(14):6732-6. doi: 10.1016/j.bmc.2008.05.061. Epub 2008 Jun 13. PMID: 18556206
Ojha AK, Baughn AD, Sambandan D, Hsu T, Trivelli X, Guerardel Y, Alahari A, Kremer L, Jacobs WR Jr, Hatfull GF. Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol Microbiol. 2008 Jul;69(1):164-74. doi: 10.1111/j.1365-2958.2008.06274.x. Epub 2008 May 5. PMID: 18466296
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr. The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis. J Bacteriol. 2007 Aug;189(15):5495-503. doi: 10.1128/JB.00190-07. Epub 2007 May 25. PMID: 17526710
Baughn AD, Malamy MH. The strict anaerobe Bacteroides fragilis grows in and benefits from nanomolar concentrations of oxygen. Nature. 2004 Jan 29;427(6973):441-4. doi: 10.1038/nature02285. PMID: 14749831
Baughn AD, Malamy MH. The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis. Microbiology (Reading). 2003 Jun;149(Pt 6):1551-1558. doi: 10.1099/mic.0.26247-0. PMID: 12777495
Baughn AD, Malamy MH. A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: implications for the evolution of the mitochondrial Krebs cycle. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4662-7. doi: 10.1073/pnas.052710199. Epub 2002 Mar 5. PMID: 11880608
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